The latest figures have been released.
1,167 new Covid-19 cases have been confirmed, as well as three further deaths.
There has now been a total of 1,868 Covid-related deaths in Ireland, while there has been 53,422 confirmed cases since the beginning of the pandemic.
263 of Wednesday's cases are in Dublin, while 142 are in Meath, 137 in Cork, 86 in Cavan and the remaining 539 cases are spread across all remaining counties.
314 people are currently in hospital with Covid, while 34 people are in ICUs across the country.
Speaking on Wednesday evening, Chief Medical Officer Tony Holohan said: "The behaviour of every individual is the most effective defence we have against the spread of Covid-19.
"Everyone needs to stay at home, other than for essential reasons.
"Follow the public health advice and treat everyone that you come into contact with as though they are a close contact of someone with Covid-19, keep your distance, avoid meeting others.
"We are facing a big challenge, but we have faced this challenge before, and that means we know how to suppress this virus, by following the public health advice in everything we do."
In Northern Ireland, Wednesday saw 1,039 new positive cases, as well as five further deaths.
