"This is a stark reminder to us all to continue to adhere to the public health guidance."
There have been 1,861 new cases of Covid-19 reported in Ireland on Wednesday.
The figures released from the Department of Health on Wednesday stated the number of total Covid-19 related deaths in Ireland now sits at 5,074.
The Department of Health's statement said the number of daily cases may also change due to future data validation.
As of 8am on Wednesday, 249 Covid-19 patients are hospitalised, of which 54 are in ICU.
Chief Medical Officer (CMO) Dr Tony Holohan said that the number of patients with the virus in both ICU and hospitals has continued to increase over recent weeks. He added that 43% of ICU cases are now in people aged under 50.
"This is a stark reminder to us all to continue to adhere to the public health guidance and to ensure to receive both Covid-19 vaccine doses as soon as it is offered.
"In the main, we have seen very high vaccination figures in our population, particularly in the over 60s cohort who were offered their vaccines first. Unfortunately, incidence of disease is increasing across all age groups.
"Covid-19 vaccines are ensuring that those who are fully vaccinated are protected from the severe illness and poor outcomes related to this disease."
The CMO added that every fully vaccinated confirmed case was preventing roughly four other cases.
Holohan said on Tuesday that the incidence rate of the virus has now climbed to the highest since January.
"As a public health doctor, I am keenly aware of the impact the public health advice has had on all in society. Making the decision not to attend work or socialise if you are displaying symptoms can be very difficult," he said.
"Our current 14-day incidence is 493 per 100,000, the highest it’s been since January 31, and incidence of disease is continuing to rise steadily in nearly all age groups and in 21 out of 26 counties."
