Bryne will now focus on her morning radio show.
RTÉ has announced that Monday's episode of Claire Byrne Live will be the last of the long-running current affairs show.
Byrne has made the decision to concentrate on her daily morning radio show on RTÉ Radio 1 as well as other projects.
Claire Byrne Live first aired in 2015 and has been a weekly staple of Irish TV since, featuring interviews, debates and a live studio audience.
"When we started Claire Byrne Live in 2015, we wanted it to be a forum for people in Ireland to shape the news, respond to unfolding events and most importantly, to have their say," Claire Byrne said.
"We came through two general elections, two hugely significant referendums and one global pandemic in the time that we have been on air.
"I have been hugely proud to be part of this show for those years and I have been humbled to work alongside three talented editors of Claire Byrne Live - Aoife Stokes, Jane Murphy and Hugh Ormond, not to mention the small, hard-working team that made sure we got to air every week, despite the massive challenges posed by the pandemic in the last two years.
"I have made the decision now to focus on my radio show and I am very much looking forward, in time, to working on other television projects for RTÉ. I want to thank everyone who made Claire Byrne Live such an enjoyable show to be part of and in particular, the audience at home, who allowed me to spend Monday nights in their company over the last seven and a half years."
RTÉ said Byrne will continue to present Today with Claire Byrne on RTÉ Radio 1, Monday to Friday from 10am, and will also work with RTÉ on future television programmes.
