The latest figures have been released.
Five additional Covid deaths have been confirmed, as well as 270 new cases.
The Republic of Ireland's Covid-related death toll now stands at 2,074, while there has now been a total of 73,066 confirmed cases.
Of Wednesday's cases, 58 are in Dublin, 38 are in Donegal, 28 are in Wicklow, 25 are in Mayo and 24 are in Limerick.
The remaining 97 cases are spread across 21 other counties.
As of 2pm today, 231 Covid-19 patients are hospitalised, of which 31 are in ICU.
27 additional hospitalisations have occurred in the past 24 hours.
Speaking on Wednesday, CMO Tony Holohan said: "When you come home from shopping or being outdoors, remember that washing your hands is your first priority."
He also confirmed that Ireland has the lowest 14 day incidence rate in the European Union. He added: "We need to hold firm. There is no room for complacency."
Earlier on Wednesday, the Northern Ireland Department of Health reported that a further 416 individuals have tested positive for Covid-19 in the past 24 hours.
Sadly, four further deaths have also been reported up north.
