Taoiseach Micheál Martin confirmed the news on Thursday evening during his nation address, stating: "You have responded extremely positively to the launch of the online portal.
"I'm pleased to confirm that over the course of next week, the portal will open for registration to all those aged 50 to 59."
called the Covid-19 vaccines "transformative" and said we are already seeing their impact in Ireland.
He explained: "Already, almost all of our most vulnerable are now protected and we can already see that the rates of death, serious illness, hospital admissions and infections in people who have been vaccinated have collapsed.
"All across the country, there are very few families that have not witnessed at first hand the sense of relief and sheer joy of a loved one receiving their vaccine. That will continue and accelerate significantly over the weeks ahead."