The vaccines were due to be administered in a nursing home.
A number of vials of the Covid-19 vaccine in the Louth and Meath area have had to be dumped as they weren't stored properly, the HSE has confirmed.
The vaccines were "stored incorrectly" and the "appropriate cold chain was not in place", and they can not be used as a result.
They were due to be distributed to a nursing home in the Midlands/Louth/Meath Community Healthcare Organisation area.
The HSE said: "It is disappointing for all concerned, residents and staff, and we are sorry that this incident has taken place. The Community Healthcare Organisation will work with national colleagues to undertake the vaccinations at the home as soon as possible.
"We're very conscious that this is upsetting news for families, residents and staff members who are working hard to protect members from Covid-19 and we are offering a range of supports to all concerned."
On Monday evening, Minister for Health Stephen Donnelly confirmed that cmmunity vaccinations will begin as planned next month despite disruptions to the delivery of the AstraZeneca vaccine.
