It will be the shamed cyclist's only public interview in Europe in 2016.
Lance Armstrong will be coming to Dublin in October to speak at a no-holds-barred interview live on stage at the RDS.
It takes place on Friday, 21 October and forms part of the inaugural One Zero sports conference.
"Lance Armstrong has been the most jaw dropping story in sport in 20 years," added co-founder Richard Barrett.
"Everyone has an opinion but very few have heard his story first hand with all the cards on the table.
“Having him speak openly and with candour about his past, with a world class interviewer - who we will be revealing shortly, is a signal of the intent of One Zero to tackle the major issues in sport from money and fans to technology and doping."
Further keynote speakers will be announced in the coming weeks as well as the full line-up of renowned panelists that will delve into such topics as e-sports, digital media, ethics in sport, fan engagement, innovation and sports investment.
"The complete speaker line- up we will be revealing in the coming weeks is like nothing Dublin has seen before," concluded co-founder Ross O’Dwyer.
General admission tickets will be on sale from 13 October from www.ticketmaster.ie
