"The spread of disease in these 370,000 people is having a disproportionate impact."
Dr Ronan Glynn has confirmed that "two out of every three people in intensive care" are unvaccinated against Covid-19.
He said almost 30,000 adults haven't come forward for vaccination, while an additional 70,000 have only had one dose.
"There has been fantastic uptake of Covid-19 vaccination over recent months," he said on Wednesday.
"Unfortunately, there are still just under 300,000 adults who have not come forward for vaccination and a further 70,000 people have received just one dose of a two-dose schedule.
"The spread of disease in these 370,000 people is having a disproportionate impact on the profile of Covid-19 in our hospitals and intensive care units, with two out of every three people in intensive care not vaccinated."
The Department of Health confirmed 2,066 new cases of the virus with 408 patients currently hospitalised and 69 in ICU. 26 deaths relating to the virus have also been newly notified in the past week.
As it stands, Ireland is set to lift all remaining Covid-19 restrictions on 22 October.
However, there is concern amongst senior Government officials over a continued rise in the number of Covid cases reported on a daily basis.
The National Public Health Emergency Team (NPHET) is set to meet next Monday to review the latest trends and to subsequently advise the Government on what steps, if any, should be taken.
