Miriam O'Callaghan will host The Late Late Show tonight
Ryan Tubridy will miss the show as he has a "persistent cough".
Miriam O'Callaghan will host The Late Late Show on Friday night.
RTÉ has said that due to a persistent cough, Ryan Tubridy is adhering to best practice and staying away from the show.
Speaking about the news, O'Callaghan said: "I'm delighted to be able to step in tonight and present the Late Late Show. We have to keep the show on the road. Best wishes to Ryan."
O'Callaghan will become the first woman to host a full episode of the show, after a young Marian Finucane once hosted the second half of an episode about feminism, as the late Gay Byrne ushered her to do so.
Global superstar Hozier will be on the show to launch an emergency on-air appeal for the ISPCC who are experiencing an upsurge in calls to Childline.
Lee Duffy, a young, fit and healthy former League of Ireland footballer, will then talk about about his harrowing experience when he contracted coronavirus and was hospitalised.
Mrs Brown's Boys stars Brendan O'Carroll and wife Jennifer Gibney will also be talking via Skype link from Florida, and comedian Dara Ó Briain will join the show from London.
Former Irish Rugby International Brian O'Driscoll will also be on tomorrow's show, as well as the legendary GAA commentator Mícheál Ó Muircheartaigh.
The Late Late Show kicks off this Friday on RTÉ One at 9.35pm.